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Next generation, cell-based liquid biopsy
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TEAM
Rex Yung MD • Chief Medical Advsior
College in Cambridge, Massachusetts. He followed up with matriculation at the University of
California in Los Angeles (UCLA), School of Medicine, and after a year in cardiovascular
research funded by an American Heart Association medical student research fellowship,
returned to clinical training in internal medicine at UCLA. His fellowship training in clinical
Pulmonary and Critical Care medicine was completed at the University of California in San
Francisco’s (UCSF) campuses and research at the UCSF Cardiovascular Research Institute.
Dr. Yung’s first academic appointment was at the University of Southern California where as an
assistant professor of pulmonary & critical care medicine, he was engaged in a broad range of
clinical activities; attending on the consult service, Surgical and Neuro intensive care units,
outpatient subspecialty clinic in Cystic Fibrosis and obstructive lung diseases. His own interest
in lung cancer, advanced diagnostic and interventional bronchoscopy led him to focus on
thoracic oncology. He was recruited to Johns Hopkins University where he served as the
Director of Pulmonary Oncology on the pulmonary service and for some years as the Director of
Bronchoscopy as well.
Nationally and internationally he has been recognized as an expert in the field of
advanced bronchoscopy and thoracic oncology, and have served in leadership positions with
the American College of Chest Physicians, Asia Pacific Society of Respirology, executive
boards of the American Association of Bronchoscopy and International pulmonology, the World
Association of Bronchology and Interventional Pulmonology amongst other national and
international subspecialty medical societies. He has conducted sponsored basic pre-clinical
and clinical research, and have served on various advisory boards of established medical
industry leaders in his field of specialty, such as Olympus, Fujinon, Karl Storz, Boston Scientific,
Philips Imaging, General Electric Imaging. He has also been on the early advisory boards of
medical technology start-ups that have successfully exited, such as PneumRx (British
Technology Group), Asthmatx (Boston Scientific). He was recruited to be the Chief Scientific
Office and subsequently the Chief Medical Officer of Prolung / IONIQ Sciences Inc., working on
biomarkers and Clinical Decision Support in lung cancer early detection. Most recently he has
been appointed the chief medical advisor to Strandsmart Inc, a leader in the field of cancer
liquid biopsies, with novel pathfinder technology to combine high yield Circulating Tumor Cell
(CTC) capture with downstream harvesting for tumor cell expression profiling in advancing non-
invasive cancer diagnosis and directing personalized therapy.
Dr. Yung remains committed to patient care and continues to see and care for patients in
the ambulatory and in-patient clinical settings. From his personal international background of
having been born and raised in East Asia, extensive collaboration with physician scientists
across North America, Europe and East Asia, he has a deep appreciation of the value of
engaging in multidisciplinary and public-private partnerships to advance the medical sciences
and effective delivery of efficacious therapies to the bedside.
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Adrianna Davies • Founder & CEO
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John Park MD • Chief Scientific Officer
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Reasons to Invest
- Utilizing liquid biopsies for precision medicine is already a $4B market and is estimated to grow to $10B by the end of the decade.
- Current technologies serving the market rely only on the DNA from tumors to drive their test results and drug prediction. StrandSmart leverages the tumor cell itself, where we can analyze and characterize the DNA, RNA, and proteins to provide a 360 view of the biologic drivers of the tumor, enabling us to develop the most accurate and comprehensive test on the market.
- Founded in 2017, we already have lab operations in Columbus, Ohio, and are backed by a management team with 8+ venture exits. Most importantly, three of the cofounders launched the first and only FDA-approved liquid biopsy CTC test.
*(source)
Overview
The future of liquid biopsy
Cancer sometimes happens so fast, it often leaves people feeling helpless in their search for solutions. That’s why at StrandSmart - instead of chasing cancer, we aim to get ahead of it, stopping it in its tracks before it makes its next move. The Company is currently pre-revenue and in the development stage.
This is now possible with technologies such as single-cell sequencing, which allows us to read the signals expressed by millions of cells at once from a given blood sample.
As a next-generation cell-based liquid biopsy company, we focus on profiling live tumor cells to guide therapy selection, patient monitoring, and therapeutic discovery & development. This is all to better help cancer patients on their road to recovery.
The Problem & Our solution
Oncologists are limited in determining how cancer patients will respond to certain treatments. Our live cell characterization provides additional information, which can enable improved decision making.
90% of cancer deaths are due to treatment failure, as cancer is a moving target that changes and evolves (source).
Liquid biopsy tests on the market today can only identify known cancer mutations - which is only about 10% of all cancers (source).
StrandSmart alerts physicians of these mutations so they can respond with alternative interventions - that we believe can lead to better outcomes. StrandSmart can extract the same mutation data as other, and in addition augment the information by adding transcriptomic, and proteomic data. The 360 degree view of cancer will predict whether a patient will respond to a drug for a much broader patient population (source). By keeping cells alive after extracting them from a blood sample, we equip oncologists and drug developers with the information needed to get the best possible outcomes for patients.
In addition, by keeping cells alive after extracting them from a blood sample, we equip oncologists and drug developers with the information needed to get the best possible outcomes for patients.
We generate revenue by selling lab tests to biotech and pharmaceutical companies that are developing cancer therapies (Research Market) and oncologists who are treating cancer patients (Cancer diagnostics).
THE MARKET & OUR TRACTION
The liquid biopsy market is a nascent industry that is experiencing rapid growth in revenue
That’s because, in the US alone, there are …
Sources: Cancer.org, Cancer.org, Cancer.org , Cancer.org, Verzenio, Komen, Zero Cancer
We are initially targeting the post-diagnosis oncology market. Our first tests are for metastatic lung, breast, and prostate cancer patients.
So far, these markets have had to rely on a limited amount of information from the sequencing of DNA for mutations only (source). With that, we believe the timing for StrandSmart is critical. Not only have we overcome the limitations of predecessor technologies for capturing Circulating-Tumor-Cells (CTCs), but the advent of single-cell sequencing technologies enables us to fully exploit them and unload the cargo of information they carry to improve outcomes.
Here’s a look at our progress to date:
WHY INVEST
Our vision is a world where cancer is no longer a terminal disease
We think cancer should be managed as a chronic disease that doesn’t interfere with the quality of life or life expectancy. With that, we want to make personalized cancer treatment accessible to everyone, and at the same time, accelerate the ability of the drug development community to develop new treatments to address all cancer diseases.
Over the next few years, we aim to…
The advent of genomics and sequencing technology over the last 10 years has already changed how we view and treat cancer with an understanding of DNA and cancer mutations.
StrandSmart sees itself as the driver of the next wave of this progress - all by putting comprehensive data of an individual patient’s cancer in the hands of the oncologists and drug developers battling the disease on the front lines. Invest in our mission today!
ABOUT
HEADQUARTERS
501 W. BROADWAY SUITE 800
SAN DIEGO, CA 92101
WEBSITE
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TERMS
StrandSmart
Overview
PRICE PER SHARE
$4.14
DEADLINE
Mar. 21, 2023 at 6:59 AM UTC
VALUATION
$18.04M
FUNDING GOAL
$10K - $1.23M
Breakdown
MIN INVESTMENT
$496.80
MAX INVESTMENT
$1,234,995.12
MIN NUMBER OF SHARES OFFERED
2,415
MAX NUMBER OF SHARES OFFERED
298,308
OFFERING TYPE
Equity
SHARES OFFERED
Common Stock
Maximum Number of Shares Offered subject to adjustment for bonus shares
*Maximum number of shares offered subject to adjustment for bonus shares. See Bonus info below.
Voting Rights of Securities Sold in this Offering
Voting Proxy. Each Subscriber shall appoint the Chief Executive Officer of the Company (the “CEO”), or his or her successor, as the Subscriber’s true and lawful proxy and attorney, with the power to act alone and with full power of substitution, to, consistent with this instrument and on behalf of the Subscriber, (i) vote all Securities, (ii) give and receive notices and communications, (iii) execute any instrument or document that the CEO determines is necessary or appropriate in the exercise of its authority under this instrument, and (iv) take all actions necessary or appropriate in the judgment of the CEO for the accomplishment of the foregoing. The proxy and power granted by the Subscriber pursuant to this Section are coupled with an interest. Such proxy and power will be irrevocable. The proxy and power, so long as the Subscriber is an individual, will survive the death, incompetency and disability of the Subscriber and, so long as the Subscriber is an entity, will survive the merger or reorganization of the Subscriber or any other entity holding the Securities. However, the Proxy will terminate upon the closing of a firm-commitment underwritten public offering pursuant to an effective registration statement under the Securities Act of 1933 covering the offer and sale of Common Stock or the effectiveness of a registration statement under the Securities Exchange Act of 1934 covering the Common Stock.
Investment Incentives and Bonuses*
Loyalty Bonus (Previous Investors):
StrandSmart would like to offer you 10% bonus shares
Time-Based:
Friends and Family
Invest within the first 48 hours and receive 15% bonus shares
Super Early Bird
Invest within the 72 hours and receive 10% bonus shares
Early Bird Bonus
Invest within the first week and receive 5% bonus shares
Amount-Based:
$5,000+
1st Tier
5% bonus shares
$10,000+
2nd Tier
10% bonus shares
$25,000+
3rd Tier
15% bonus shares
*In order to receive perks from an investment, one must submit a single investment in the same offering that meets the minimum perk requirement. Bonus shares from perks will not be granted if an investor submits multiple investments that, when combined, meet the perk requirement. All perks occur when the offering is completed.
The 10% StartEngine Owners' Bonus
SmartStrand, Inc. will offer 10% additional bonus shares for all investments that are committed by investors that are eligible for the StartEngine Crowdfunding Inc. OWNer's bonus.
This means eligible StartEngine shareholders will receive a 10% bonus for any shares they purchase in this offering. For example, if you buy 100 shares of Common Stock at $4.14 / share, you will receive 110 shares of Common Stock, meaning you'll own 110 shares for $414. Fractional shares will not be distributed and share bonuses will be determined by rounding down to the nearest whole share.
This 10% Bonus is only valid during the investors eligibility period. Investors eligible for this bonus will also have priority if they are on a waitlist to invest and the company surpasses its maximum funding goal. They will have the first opportunity to invest should room in the offering become available if prior investments are canceled or fail.
Investors will receive the highest single bonus they are eligible for among the bonuses based on the amount invested and time of offering elapsed (if any). Eligible investors will also receive the Owner’s Bonus and the Prior Investor Loyalty Bonus in addition to the aforementioned bonus.
Irregular Use of Proceeds
ALL UPDATES
03.06.23
Our community joins in!
We're excited to see our community come in and invest in StrandSmart! Our Insiders have invested a total of $4,569.62 into the offering to date! We hope you join in as well!
Please refer to the Company’s offering materials for further information and refer to the Company’s Risk Factors.
REWARDS
10%
Stack Venture Club & Rewards!
Members get an extra 10% shares in addition to rewards below!
Venture Club
Venture Club Members earn 10% bonus shares on top of this and all eligible investments for an entire year. Not a member? Sign up at checkout ($275/year).
$5,000
1st Tier
5% bonus shares
$10,000
2nd Tier
10% bonus shares
$25,000
3rd Tier
15% bonus shares
JOIN THE DISCUSSION
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David Schrift
2 years ago
Hi, I had a few questions on revenue generation: 1. Can you elaborate on your timeline and pipeline for revenue generation with research/pharmaceutical firms? Do you have firms lined up? Expected range of revenue for each firm? Expected total yearly revenue? Margin expectations? 2. What are the barriers for long term revenue generation with commercialization and how do you plan on addressing them? (What is needed for FDA approval and timeline? How do you plan to get widespread adoption with oncologists? What type of studies do you expect to need to achieve these goals and how long and how expensive do you expect the studies to be?) Thank you! David
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HOW INVESTING WORKS
Cancel anytime before 48 hours before a rolling close or the offering end date.
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FAQS
With Regulation A+, a non-accredited investor can only invest a maximum of 10% of their annual income or 10% of their net worth per year, whichever is greater. There are no restrictions for accredited investors.
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Janice Makela
2 years ago
Hi, A test is only as good as the information it gives. Some examples are test like CEA, which might help monitor disease progression but is useless as a screen. Or tests for incurable untreatable diseases. And those are the test that make it to the market. There are several other markers in cancer cells that are useless, because they don't give any info about treatment or prognosis. Though something like HER1/2 can give prognostic and treatment information. What usable information does you test give? You call yourself a liquid biopsy (blood). What does that mean? If you are getting the cancer cells from the blood, does that mean it has already metastasized? Does the tech have any potential in solid tumors that have not metastasized? How far along in your research are you? Do you have any potential markers you are working on? Or is your revenue in the tech you sell to researchers so they can develop markers? Thanks.
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